The series follows the ups and downs of third-generation restaurateur BOB (H. Jon Benjamin), who runs Bob's Burgers with the help of his wife and their three kids. Bob and his unpredictable family have big ideas about burgers, but they fall short on service and sophistication. Despite their restaurant's greasy counters, lousy location and dearth of customers, Bob and his family are determined to make every "Grand Re-Re-Re-opening" a success.

　　这部动画剧的场景非常丰富：「鲍勃汉堡店」的隔壁是一家带火葬场的殡仪馆；街道尽头是旅游码头；几个街区外是市属中学，Bob和Linda的孩子们就在那里读书；街对面是Bob的竞争对手Jimmy Pesto开设的披萨饼店，匹萨对汉堡的大战每天都在上演。